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KMID : 0043319920150030191
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Archives of Pharmacal Research
1992 Volume.15 No. 3 p.191 ~ p.195
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Synthesis of 6’’-Substituted Dobutamine Analogues
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Yoon SH
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Abstract
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Two 6’’-substituted dobutamine analogues (1, 2) were synthesized from the coupling reaction of dopamine with the corresponding ketones. The ketone (8) was obtained from 4-nitrosalicylaldehyde via 6 synthetic steps while the ketone (12) was prepared from 2-methyl-5-nitrobenzoic acid via 7 synthetic steps. Another synthetic attempts were also reported.
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